Beyaz can help women get the recommended daily amount of folate as part of their oral contraceptive (OC) routine, for those women who choose an OC for contraception

  • The Centers for Disease Control and Prevention (CDC) and the U.S. Preventive Services Task Force (USPSTF) recommend that all women of childbearing age supplement their diet with at least 400 mcg of folic acid daily to reduce the risk of a neural tube defect (NTD)1,2*
  • Beyaz combines drospirenone (drsp®) 3 mg/ethinyl estradiol (EE) 20 mcg with a B vitamin, levomefolate calcium 451 mcg – an equimolar dose to folic acid 400 mcg
  • Counsel patients to report whether they are taking folate supplements. Ensure that folate supplementation is maintained if a woman discontinues Beyaz

The only OC with 4 FDA-approved indications for women who choose an OC for contraception

  • Prevention of pregnancy – 99% contraceptive efficacy when used as directed
  • Treatment of the symptoms of premenstrual dysphoric disorder (PMDD)
    • The effectiveness of Beyaz for PMDD when used for more than 3 menstrual cycles has not been evaluated. Beyaz has not been evaluated for the treatment of premenstrual syndrome (PMS)
  • Treatment of moderate acne for women at least 14 years of age who have achieved menarche

indicated for women who choose an OC for contraception to

  • Raise folate levels for the purpose of reducing the risk of an NTD in a pregnancy conceived while taking the product or shortly after discontinuing the product
    • Beyaz is not indicated during pregnancy
    • Plasma folate levels are likely to return to baseline ~20 weeks after discontinuation

Available in Pharmacies

Every pill in this 24/4-day OC regimen contains levomefolate calcium 451 mcg

drsp 3 mg/EE 20 mcg + levomefolate calcium 451 mcg


levomefolate calcium 451 mcg

Bayer Savings Card

Click card for full program details

Restrictions apply

Important Safety Information About BEYAZ, Including Boxed Warning

Patients who should not take Beyaz

Women over 35 years old who smoke should not use Beyaz. Smoking increases the risk of serious cardiovascular side effects from Beyaz use. This risk increases with age and the number of cigarettes smoked.

Know serious risks with Beyaz

Please see provided full Prescribing Information about Beyaz, including Boxed Warning.

* The health authorities cited do not endorse specific products or brands.

1. Centers for Disease Control and Prevention. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR. 1992;41(RR-14):1-7.
2. U.S. Preventive Services Task Force. Folic acid for the prevention of neural tube defects: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2009;150:626-631.

BAYER®, the Bayer Cross®, Beyaz®, drsp®, and Aleve® are trademarks of Bayer.
All other trademarks are the property of their respective owners.


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.